Benzylpenicillin versus flucloxacillin for penicillin-susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study

A Henderson; P Harris; G Hartel; D Paterson; J Turnidge; JS Davis; SYC Tong

Journal article

Benzylpenicillin versus flucloxacillin for penicillin-susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study

A Henderson, P Harris, G Hartel, D Paterson, J Turnidge, JS Davis, SYC Tong

International Journal of Antimicrobial Agents | ELSEVIER | Published : 2019

DOI: 10.1016/j.ijantimicag.2019.05.020

Abstract

In clinical practice, differing opinions exists regarding the optimal management of patients with penicillin-susceptible Staphylococcus aureus (PSSA) bloodstream infection (BSI). The aim of this study was to compare the 30-day mortality of patients treated with benzylpenicillin or flucloxacillin for PSSA BSI from a large prospectively collected data set from Australia and New Zealand. A logistic regression model and propensity score treatment analysis using inverse probability of treatment weighting were used. A total of 915 patients were included in the study, with an overall mortality rate of 12.9% (118/915) [benzylpenicillin 10.5% (33/315) and flucloxacillin 14.2% (85/600)]. Endocarditis ..

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University of Melbourne Researchers

Steven Tong Author

Related Projects (1)

CLINICAL AND GENOMIC ASPECTS OF STAPHYLOCOCCUS AUREUS AND OTHER INFECTIOUS DISEASES IN NORTHERN AUSTRALIA

The burden of infectious disease is high in Indigenous populations in northern Australia and patterns of disease differ. My research propose..

Grants

Awarded by Australian Society of Antimicrobials

Funding Acknowledgements

Support for ANZCOSS data collection was generously granted by the Australian Society for Antimicrobials (ASA). The ASA had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. JSD and SYCT received salary support from Australia's National Health and Medical Research Council [Career Development Fellowships #1083105 and #1065736, respectively].